In the highly acclaimed Stake Land, hailed by some critics as "the American horror film of the year", the US has become a lost nation. When an epidemic of vampirism strikes, humans find themselves on the run. Cities are tombs and survivors cling together in rural pockets, fearful of nightfall. When his family is slaughtered, young Martin (Connor Paolo) is taken under the wing of a grizzled, wayward hunter whose new prey are the undead. Simply known as Mister (Nick Damici), he takes Martin under his wing on a journey through the locked-down towns of America's heartland, battling against not only feral vampires but also the fanatical savagery of the right wing religious cult known as The Brotherhood, in search of the fabled safe haven, New Eden.