In a remote lab outside of Dallas, Texas, a medical experiment goes horribly wrong. The subject experiences a psychotic break after being administered a text vaccine and ends up deceased. The board of directors of the pharmaceutical company plans to shut the facility down in the wake of the disaster, but the lead scientist (Danny Glover), convinces them to give him one more week to test the vaccine on a subject who they are monitoring at a nearby residence. Meanwhile, upon arriving from a tour of duty in the Middle East, Dean Pierce (Taylor Handley) and his girlfriend Mandy (Margo Harsham) and his friends set out on a road trip to Mentryville to clean up his hoarding and ageing grandmother's remote home and save her from eviction. The lab learns that Dean and his friends have compromised their subject who may possess the DNA for the successful vaccine discovery, so they send in a private armed guard (Vinnie Jones) to keep the group from leaving the property alive. One by one, the virus infects Dean's friends as they are trapped inside the house. Dean and his friends find themselves fighting for their lives.