Emmy Award winner Raymond Burr reprises his role as the wheelchair bound Robert T. Ironside. Raymond Burr is reunited with stars of the original series: Don Galloway, Barbara Anderson, Elizabeth Baur and Don Mitchell.

Ironside is about to retire as head of the San-Francisco Police Department to finally fulfill his dream - running his own vineyard. However when Ed Brown, his former chief aid, now Deputy Chief, asks him to take over the Denver Police Department because of the murder of the former Chief of Police, Ironside agrees to do so.