In New Orleans, only one man stands between the living and the dead. That man is Dylan Dog (Brandon Routh, Superman Returns, Scott Pilgrim Vs. The World), a private investigator who has recently left behind his role as a mediator between the human world and the creatures of the night.

When he receives a call from the beautiful Elizabeth (Anita Briem, The Tudors), whose wealthy father has died in mysterious circumstances, Dylan soon deduces that the murderer is not human. With Elizabeth along for the ride, the investigation leads Dylan to face-off with the leaders of the werewolf and vampire clans.