The genetically enhanced snakes from Anaconda 3: Offspring are dead, but one of their slithering offspring has regenerated to live on in this next action-packed chapter of the Anaconda franchise. The dying mogul, Murdoch (Emmy®-Nominated actor John Rhys-Davies), hires a doctor to harvest a fresh supply of blood orchids and experiment with the regenerative nectar on a baby snake. Overnight, the offspring grows monstrous enough in size and appetite to devour the good doctor whole, before slithering free on a regenerative rampage. The beautiful herpetologist, Amanda (Crystal Allen), dedicated to destroying the vicious beasts she helped create, leads a team of young scientists against a ruthless pack of Murdoch's armed thugs to get the coveted orchids before the snake hunts both factions down. The bloodthirsty offspring is seemingly invincible, sliding through explosions and gunfire only to regenerate and prey insatiably on anything in its path.