Something mysterious is leaving a path of destruction in the streets of 1926 New York, threatening to expose the wizarding community. Newt Scamander arrives in the city nearing the end of a global excursion to research and rescue magical creatures. When unsuspecting No-Maj Jacob Kowalski inadvertently lets some of Newt's beasts loose, a band of unlikely heroes must rediscover the missing beasts before they come to harm, but their mission puts them on a collision course with dark forces.