In 1888 London, the unfortunate poor live horrifying lives in the city's slums. Harassed by gangs and forced to walk the streets for a living, Mary Kelly (Graham) and her small group of companions are terrorized when their friend is kidnapped and another in their group is gruesomely murdered. The sinister murder gains the attention of Inspector Fred Abberline (Depp), a brilliant yet troubled man whose police work is often aided by his psychic abilities. Abberline becomes deeply involved in the case and he gets closer to the truth, it becomes more dangerous for Abberline, Mary and the other girls. Will they be able to survive the avenging force that has been sent after them from Hell?