To celebrate the dramatic close of a backbreaking case, Sherlock Holmes and Dr. Watson go on holiday to Africa's breathtaking Victoria Falls. They indulge in a luxurious train ride on board the 'Orient Express', hobnobbing with the most glamorous personalities of the day. But there is to be no rest for the great Holmes, for someone is killed and one of the passengers is the murderer... Soon everyone is a suspect, the beautiful temptress Lily Langtry, the great Italian inventor Guglielmo Marconi and even former president Teddy Roosevelt.