Sultry crime boss Lucy Diamond (Jordana Brewster) is back in the states and the D.E.B.S.- an elite team of paramilitary college superspies- are hot on her trail. But when their top agent, gorgeous Amy Bradshaw (Sara Foster), mysteriously disappears after coming face to face with the attractive young villainess, the D.E.B.S. begin a full-scale search for Lucy's secret lair, never suspecting that Amy may not want to be rescued after all, in this smart and sexy spy spoof.